Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: Five (5) Drops
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%
Total Sugars
0 g
**
Incl. 0 g Added Sugars
**
Vitamin D (as cholecalciferol)
10 mcg (400 IU)
100%
Probiotic Blend
29 mg (2.5 billion CFUs)
Lactobacillus rhamnosus GG
**
Bifidobacterium animalis subsp. lactis (BB-12®)
**
Top Medical Research Studies
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
9
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
Read More
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
Read More
Most Useful Reviews
9
Relieved gas and colic
1 people found this helpful
These probiotics are fantastic. My child began suffering from tummy troubles from the second week after birth. After starting these probiotics, I noticed that my baby could pass stools without any issues, and after a while, the gas and colic disappeared. I highly recommend them!
Read More
9
Recommended probiotic
An excellent probiotic for a baby's tummy adaptation. I highly recommend it; there is a noticeable effect.
Read More
7.5
Improved digestive health
I highly recommend this! My baby had been quite constipated and gassy, which made her very fussy. Within days of use, I noticed she was less gassy and having bowel movements more regularly. Being exclusively breastfed, I appreciated that it also contains vitamin D. Since using it every day, I've definitely noticed improvements in her digestive health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
- All Researches
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
9
We investigated the effects of Lactobacillus rhamnosus on high cholesterol and blood sugar levels in diabetic rats.
By using yogurt fermented with this probiotic, we noticed significant reductions in blood glucose and an increase in healthy cholesterol levels.
Within just four days of consuming the yogurt, notable changes in liver and kidney enzymes were observed, alongside improvements in lipid profiles.
While promising, further research is needed to confirm these benefits in humans.
By using yogurt fermented with this probiotic, we noticed significant reductions in blood glucose and an increase in healthy cholesterol levels.
Within just four days of consuming the yogurt, notable changes in liver and kidney enzymes were observed, alongside improvements in lipid profiles.
While promising, further research is needed to confirm these benefits in humans.
Read More
9
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Read More
9
We explored how two specific probiotic strains, Lactobacillus johnsonni 3121 and Lactobacillus rhamnosus 86, impact high cholesterol conditions linked to obesity. In our study using obese mice on a high-fat diet, we observed that daily doses of these probiotics over 12 weeks led to significant improvements in cholesterol levels.
Notably, both strains reduced lipid accumulation and influenced the genes involved in fat cell development. Additionally, they helped restore the balance of gut bacteria affected by obesity. These findings suggest that these probiotics could be valuable in managing high cholesterol and obesity-related health issues.
Notably, both strains reduced lipid accumulation and influenced the genes involved in fat cell development. Additionally, they helped restore the balance of gut bacteria affected by obesity. These findings suggest that these probiotics could be valuable in managing high cholesterol and obesity-related health issues.
Read More
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieved gas and colic
1 people found this helpful
These probiotics are fantastic. My child began suffering from tummy troubles from the second week after birth. After starting these probiotics, I noticed that my baby could pass stools without any issues, and after a while, the gas and colic disappeared. I highly recommend them!
Read More
9
Recommended probiotic
An excellent probiotic for a baby's tummy adaptation. I highly recommend it; there is a noticeable effect.
Read More
7.5
Improved digestive health
I highly recommend this! My baby had been quite constipated and gassy, which made her very fussy. Within days of use, I noticed she was less gassy and having bowel movements more regularly. Being exclusively breastfed, I appreciated that it also contains vitamin D. Since using it every day, I've definitely noticed improvements in her digestive health.
Read More
6
Effective against colic
It calms colic and constipation effectively. I’m giving it to my first baby. However, the quantity is quite small, and the price is a bit high.
Read More
Frequently Asked Questions
9
Relieved gas and colic
1 people found this helpful
These probiotics are fantastic. My child began suffering from tummy troubles from the second week after birth. After starting these probiotics, I noticed that my baby could pass stools without any issues, and after a while, the gas and colic disappeared. I highly recommend them!
7.5
Improved digestive health
I highly recommend this! My baby had been quite constipated and gassy, which made her very fussy. Within days of use, I noticed she was less gassy and having bowel movements more regularly. Being exclusively breastfed, I appreciated that it also contains vitamin D. Since using it every day, I've definitely noticed improvements in her digestive health.
9
Recommended probiotic
An excellent probiotic for a baby's tummy adaptation. I highly recommend it; there is a noticeable effect.
8
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
References
- Liu ZY, Liu S, Yao X, Wang CY, Song Y, et al. A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults. Front Nutr. 2024;11:1492621. 10.3389/fnut.2024.1492621
- Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. 10.1093/nutrit/nuae226
- Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
- Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. 10.1615/CritRevImmunol.2024052129
- Li X, Liu Y, Wang J, Chen X, Reichetzeder C, et al. Vitamin D Is Associated with Lipid Metabolism: A Sex- and Age-Dependent Analysis of a Large Outpatient Cohort. Nutrients. 2024;16. 10.3390/nu16223936
- Hu T, Zhang Y, Chen Z, Su J. Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018. Front Nutr. 2024;11:1468284. 10.3389/fnut.2024.1468284
- Xu H, Qiu S, Lin P, Liao X, Lin Y, et al. Vitamin D has therapeutic effects on obesity and hyperandrogenemia in PCOS mouse model induced by low dose DHEA and high-fat diet. BMC Womens Health. 2024;24:601. 10.1186/s12905-024-03445-w
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Wang J, Shi T, Xu L, Li Y, Mi W, et al. Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort. Front Nutr. 2024;11:1302260. 10.3389/fnut.2024.1302260
- Correia Gomes D, Meza Alvarado JE, Zamora Briseño JA, Cano Sarmiento C, Camacho Morales A, et al. Maternal Supplementation with GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring. Diseases. 2024;12. 10.3390/diseases12120312
- Dang L, Li D, Mu Q, Zhang N, Li C, et al. Youth-derived Lactobacillus rhamnosus with prebiotic xylo-oligosaccharide exhibits anti-hyperlipidemic effects as a novel synbiotic. Food Res Int. 2024;195:114976. 10.1016/j.foodres.2024.114976
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. 10.3390/nu16091331
- Negm El-Dein A, Ezzat A, Aly HF, Awad G, Farid M. Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutr Res. 2022;108:22. 10.1016/j.nutres.2022.10.003
- Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, et al. FM9 and Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022;14. 10.3390/nu14081654
- Yoon H, Lee Y, Kang HJ, Ju J, Ji Y, et al. Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. J Appl Microbiol. 2022;132:562. 10.1111/jam.15181
- Daliri EB, Kim Y, Do Y, Chelliah R, Oh DH. In Vitro and In Vivo Cholesterol Reducing Ability and Safety of Probiotic Candidates Isolated from Korean Fermented Soya Beans. Probiotics Antimicrob Proteins. 2022;14:87. 10.1007/s12602-021-09798-0
- Lee CS, Park MH, Kim BK, Kim SH. Antiobesity Effect of Novel Probiotic Strains in a Mouse Model of High-Fat Diet-Induced Obesity. Probiotics Antimicrob Proteins. 2021;13:1054. 10.1007/s12602-021-09752-0
- El-Dein AN, Nour El-Deen AM, El-Shatoury EH, Awad GA, Ibrahim MK, et al. Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp. Int J Biol Macromol. 2021;173:66. 10.1016/j.ijbiomac.2021.01.107
- Das S, Mishra BK, Hati S. Techno-functional characterization of indigenous isolates from the traditional fermented foods of Meghalaya, India. Curr Res Food Sci. 2020;3:9. 10.1016/j.crfs.2020.01.002
- Romão da Silva LF, de Oliveira Y, de Souza EL, de Luna Freire MO, Braga VA, et al. Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Food Funct. 2020;11:7152. 10.1039/d0fo01661f
- Wa Y, Yin B, He Y, Xi W, Huang Y, et al. Effects of Single Probiotic- and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats. Front Microbiol. 2019;10:1312. 10.3389/fmicb.2019.01312
- Yan Y, Zhang F, Chai Z, Liu M, Battino M, et al. Mixed fermentation of blueberry pomace with L. rhamnosus GG and L. plantarum-1: Enhance the active ingredient, antioxidant activity and health-promoting benefits. Food Chem Toxicol. 2019;131:110541. 10.1016/j.fct.2019.05.049
- Park S, Kang J, Choi S, Park H, Hwang E, et al. Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PLoS One. 2018;13:e0203150. 10.1371/journal.pone.0203150
- Oh NS, Joung JY, Lee JY, Kim Y. Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces. PLoS One. 2018;13:e0192021. 10.1371/journal.pone.0192021
- Roselli M, Devirgiliis C, Zinno P, Guantario B, Finamore A, et al. Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition. Genes Nutr. 2017;12:25. 10.1186/s12263-017-0583-1
